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Unravelling Methylation: The Role of Key Genes in Your Health

Methylation is a critical biochemical process that occurs billions of times per second within our cells, playing a key role in gene expression, detoxification, neurotransmitter function, and overall health. This process involves transferring a methyl group (one carbon and three hydrogen atoms) to other molecules, influencing their activity. Understanding the key genes involved—MTHFR, MTR, MTRR, AHCY, COMT, and others—sheds light on how our bodies regulate essential functions and how genetic variations can impact health.

 

Key Genes in Methylation

MTHFR (Methylenetetrahydrofolate Reductase)

The MTHFR gene is widely recognised for its role in converting folate (vitamin B9) into its active form, 5-MTHF, which is crucial for homocysteine metabolism and DNA synthesis. Variants such as C677T and A1298C can reduce enzyme efficiency, leading to elevated homocysteine levels—linked to cardiovascular disease, neurological issues, and pregnancy complications. Adequate intake of methylated B vitamins can help support methylation in individuals with these variants.

 

 

MTR (Methionine Synthase) & MTRR (Methionine Synthase Reductase)

MTR is essential for the conversion of homocysteine into methionine, a key amino acid involved in protein synthesis and methylation pathways. MTRR maintains the function of MTR by ensuring active vitamin B12 availability. Variants in these genes may impair methionine synthesis, leading to methylation imbalances and increased health risks, including cognitive decline and cardiovascular issues.

 

 

AHCY (Adenosylhomocysteinase)

AHCY facilitates the breakdown of S-adenosylhomocysteine (SAH) into homocysteine, preventing toxic buildup. Disruptions in AHCY function can lead to metabolic disturbances and heightened oxidative stress, impacting cardiovascular and neurological health.

 

 

COMT (Catechol-O-Methyltransferase)

COMT is responsible for methylating and breaking down neurotransmitters like dopamine, epinephrine, and norepinephrine. Genetic variations can influence mood regulation, stress response, and cognitive function. Individuals with COMT variants may benefit from optimising their methylation balance through tailored nutrition and stress management strategies.

 

 

The Bigger Picture: Methylation and Personalised Health

Methylation is not dictated by genetics alone—environmental factors, diet, and lifestyle choices significantly influence its efficiency. Advanced genetic testing enables the identification of key variations, allowing for precise interventions such as optimised nutrition, methylated B-vitamin supplementation, and lifestyle modifications to support optimal methylation.

 

Life X DNA provides cutting-edge analysis of 26 key methylation genes, as well as hundreds of other markers influencing detoxification, neurotransmitter balance, and overall metabolic health. Our personalised reports help individuals make informed decisions to enhance their wellbeing and reduce genetic risk factors.

 

Understanding methylation through a functional genomics lens empowers individuals to take proactive steps in managing their health. By fine-tuning methylation pathways, we can unlock better energy levels, cognitive clarity, and overall longevity.

 

Stay informed, stay optimised.

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