Is Histamine Intolerance Genetic? – Genes That Affect Histamine Breakdown

We look at over 900,000 SNP’s and use the latest AI powered software to analyse over 80 million variants that significantly influence your health.

If you experience flushing, headaches, hives or digestive issues after eating certain foods, you might be dealing with histamine intolerance. While diet plays a major role, your genes may also contribute.

At Life X DNA, our reports include key genes related to histamine clearance and immune reactivity. Our test kits are available across Australia and New Zealand and help explore whether your body processes histamine efficiently.

Genetic Methylation Tests Melbourne

Why Do I React to Everything I Eat?

Some people are especially sensitive to histamine-rich or histamine-releasing foods like aged cheese, wine, fermented vegetables or smoked meats.

Common reactions include:

  • Skin flushing or itching
  • Headaches or dizziness
  • Nasal congestion
  • Digestive upset or bloating
  • Fatigue after meals

If you react to multiple foods or supplements, your ability to break down histamine may be reduced.

Genes Linked to Histamine Intolerance

Histamine is broken down in the body by specific enzymes. If the genes responsible for those enzymes contain certain variants, your breakdown rate may be slower.

Key genes include:

  • DAO (diamine oxidase) – breaks down histamine in the gut
  • HNMT – processes histamine inside cells
  • AOC1 – encodes the DAO enzyme
  • ALDH2, MAOA – influence breakdown of histamine-like compounds

Life X DNA reports analyse these genes and show how they may influence your histamine tolerance.

MTHFR Tests Melbourne
DNA Health Tests Melbourne

Is Histamine Intolerance Genetic or Gut-Related?

Often it’s both. Genetics may reduce your enzyme activity, and gut issues like leaky gut, SIBO or inflammation may further lower your tolerance.

Your report also includes:

  • Gut barrier genes (e.g. FUT2, MUC family)
  • Immune sensitivity genes that may amplify food reactions
  • Inflammation and oxidative stress pathways that affect tolerance thresholds

Genetic Testing for Histamine Intolerance Traits

Life X DNA testing provides insights into:

  • Whether your DAO gene variants affect enzyme activity
  • How efficiently you clear histamine from cells
  • Interactions between your gut genes and food sensitivity risk
  • Nutrients that may support clearance (e.g. B2, copper, vitamin C)

These insights are not diagnostic but can help guide personalised strategies or clinical discussions.

Genetic Methylation Tests New Zealand

Available in Australia and New Zealand

All Life X DNA kits are processed in our ISO-certified lab in Perth and available AU/NZ-wide. Your results are securely delivered and never shared or sold.

FAQs – Genetics and Histamine Intolerance

Yes. Genes like DAO and HNMT influence how quickly your body breaks down histamine. Slow variants may increase sensitivity to foods or supplements.

DAO (diamine oxidase) breaks down histamine in the gut. Certain genetic variants can reduce enzyme function and contribute to symptoms.

Life X DNA reports show which histamine-related variants you carry and how they may affect your ability to process histamine-rich foods.

Order online, collect your cheek swab, and return it to our Perth-based lab. Your secure report will be available digitally through our private portal.