Is Estrogen Dominance Genetic? – Understanding Your Hormone Detox Pathways

We look at over 900,000 SNP’s and use the latest AI powered software to analyse over 80 million variants that significantly influence your health.

If you’ve experienced bloating, mood swings, breast tenderness or heavy periods, you might have been told it’s “estrogen dominance.” But what does that mean, and can genetics play a role?

For some people, inherited differences in detoxification and hormone clearance pathways may affect how efficiently estrogen is processed. Life X DNA™ reports include gene analysis that can provide personalised insights into hormone regulation and metabolism.

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Can Estrogen Dominance Be Genetic?

Yes. Estrogen levels are influenced not only by what your body produces, but also by how well you clear used hormones from circulation. This process is largely handled through detoxification pathways – and those can vary by genetics.

Key genes that may affect estrogen processing include:

  • COMT – breaks down catechol estrogens via methylation
  • GSTM1 and GSTP1 – detoxify estrogen metabolites
  • CYP1B1 – involved in estrogen hydroxylation
  • MTHFR and BHMT – support methylation pathways that regulate hormone balance

Variations in these genes may affect how estrogen is metabolised, potentially increasing the buildup of more reactive forms in the body.

Genetic Testing for Estrogen Detox and Hormone Sensitivity

Life X DNA™ testing explores the pathways most involved in hormone metabolism, including:

  • Phase I (modification) and Phase II (clearance) detox genes
  • Methylation efficiency for estrogen breakdown
  • Glutathione and antioxidant systems that protect against estrogen-related oxidative stress

These insights are not diagnostic, but they may help explain sensitivity to hormonal changes, contraceptive side effects, or perimenopausal symptoms.

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DNA Health Tests Melbourne

Why Am I Sensitive to Hormonal Shifts?

Some people are more prone to hormone fluctuations, and this sensitivity may be amplified by:

  • Slower estrogen clearance
  • Poor detox enzyme activity
  • Genetic difficulty methylating catechol estrogens
  • Inflammation or oxidative stress that impacts hormone recycling

Your Life X DNA™ report helps identify these tendencies and provides guidance on nutrients or strategies that may support estrogen metabolism.

What’s Included in Your Report

Hormone-related content appears across several sections:

  • COMT and estrogen methylation
  • GST and Phase II detoxification
  • MTHFR, BHMT and folate cycle efficiency
  • CYP enzymes and estrogen breakdown balance

All Life X DNA™ kits are processed in our ISO-certified Perth lab. Reports are securely delivered through our digital portal.

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Available in Australia and New Zealand

Our at-home DNA kits are available across Australia and New Zealand, with return shipping included. Your data is protected, and results are delivered through a secure online platform.

FAQs – Estrogen and Genetic Detox Pathways

It can be influenced by genetics. Variants in COMT, GST and methylation genes may affect how efficiently your body clears estrogen metabolites.

You may have inherited slower detox pathways or reduced methylation capacity. This could increase hormone sensitivity, even if levels are normal.

We analyse COMT, GSTM1, CYP1B1, MTHFR, BHMT and others involved in hormone metabolism and detoxification.

Order your Life X DNA™ kit online, collect a cheek swab at home, and return it to our Perth lab. Your report will be available securely online.