Folic Acid Sensitivity – Could Your Genes Be Involved?

We look at over 900,000 SNP’s and use the latest AI powered software to analyse over 80 million variants that significantly influence your health.

If you’ve ever felt worse after taking a standard multivitamin or folic acid supplement, you’re not alone. Some people experience fatigue, irritability, headaches or anxiety after folic acid – and genetics may be part of the reason.

At Life X DNA™, we include key folate pathway genes in every report. Our at-home test kits are available across Australia and New Zealand and provide insight into whether your body processes synthetic folic acid efficiently.

Genetic Methylation Tests Melbourne

Why Does Folic Acid Make Me Feel Worse?

Folic acid is the synthetic form of folate commonly used in supplements and fortified foods. While it works well for many people, others may have trouble converting it into the active form (5-MTHF), which the body actually uses.

This can lead to unmetabolised folic acid buildup or disrupted methylation activity – particularly in people with lower enzyme function due to inherited gene variants.

Genes That Influence Folic Acid Processing

Several genes affect how your body handles folate and folic acid:

  • MTHFR – converts folate into the active methylated form
  • DHFR – processes synthetic folic acid before it can be used
  • MTR and MTRR – support B12-folate interaction in methylation
  • SLC19A1 – helps transport folate into cells

When these genes have certain variants, folic acid may not be converted efficiently, and excess may disrupt other nutrient pathways or mood regulation.

MTHFR Tests Melbourne
DNA Health Tests Melbourne

Genetic Testing for Folate Sensitivity and Methylation Support

Life X DNA™ testing provides insights into:

  • Whether MTHFR or DHFR variants may affect folic acid metabolism
  • How efficiently you convert and transport folate
  • Methylation performance across the broader folate/B12/choline cycle
  • Risk of unmetabolised folic acid buildup or methylation imbalance

Our reports are educational, not diagnostic, and are best used to guide nutrient format choices or personalised health strategies.

What’s Covered in Your Life X DNA™ Report

Folate metabolism and methylation-related content includes:

  • MTHFR C677T and A1298C genotypes
  • DHFR, MTR, MTRR and SLC19A1 variants
  • Related genes for B12 and choline interaction
  • Over 1200 pages of structured genetic insights

All kits are processed in our ISO-certified Perth lab and delivered via secure digital portal.

MTHFR Tests Sydney

Available in Australia and New Zealand

Life X DNA™ test kits are available throughout Australia and New Zealand. Return shipping is included. Your data is private, secure and never shared.

FAQs – Folic Acid and Genetics

You may have reduced activity in enzymes that process synthetic folic acid. This can disrupt methylation or cause unmetabolised folic acid to build up.

No. Blood folate levels can appear normal even when folic acid isn’t being converted efficiently. Genetic insight helps explain this mismatch.

We include MTHFR, DHFR, MTR, MTRR and related genes involved in folate activation, transport and methylation.

Order online, collect your cheek swab at home, and return the sample to our Perth lab. Your personalised report is securely delivered online.