Mitochondrial Dysfunction Symptoms – Could Genetics Be a Factor?

We look at over 900,000 SNP’s and use the latest AI powered software to analyse over 80 million variants that significantly influence your health.

If you experience low energy, muscle fatigue, poor recovery or brain fog despite getting rest, you may be dealing with symptoms related to mitochondrial dysfunction. While this term is often used loosely, there are genetic factors that can affect how well your cells produce energy.

Life X DNA™ reports include analysis of genes involved in mitochondrial efficiency, antioxidant response and cellular metabolism. Our test kits are available across Australia and New Zealand and may help explain why your body doesn’t bounce back like it used to.

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What Are the Symptoms of Mitochondrial Dysfunction?

Mitochondria are the “engines” of your cells, responsible for producing usable energy (ATP) from food and oxygen. When this system is inefficient, common symptoms may include:

  • Persistent physical or mental fatigue
  • Muscle weakness or poor stamina
  • Sensitivity to exercise or exertion
  • Poor stress recovery
  • Difficulty concentrating or memory lapses

These symptoms can be caused by many factors, but underlying genetic variation may reduce your mitochondrial resilience or efficiency.

Can Mitochondrial Dysfunction Be Genetic?

Yes. Many genes support mitochondrial health, including those that:

  • Help convert nutrients into cellular energy
  • Neutralise oxidative stress
  • Regulate mitochondrial growth and repair
  • Handle stress and inflammation that damage mitochondria

Key genes include:

  • NQO1 – supports antioxidant recycling and mitochondrial enzymes
  • UCP2 – regulates mitochondrial efficiency and heat generation
  • SOD2 – protects mitochondria from oxidative damage
  • MT-ND family – involved in the mitochondrial respiratory chain
  • PGC-1α (PPARGC1A) – regulates mitochondrial biogenesis

Variants in these genes may contribute to long-term low energy, poor exercise recovery or stress-induced fatigue.

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Genetic Testing for Mitochondrial Function and Energy Support

Life X DNA™ testing provides insight into:

  • Mitochondrial performance and oxidative stress sensitivity
  • Nutrient pathways that support cellular energy (e.g. B2, carnitine, CoQ10)
  • Inflammation and detox factors that may impair energy conversion
  • Recovery speed after mental or physical stress

These results do not diagnose mitochondrial disease but may help you understand if your baseline energy systems are genetically under strain.

What’s Included in Your Life X DNA™ Report

Your mitochondrial profile includes:

  • Antioxidant, stress and mitochondrial efficiency genes
  • Cofactor metabolism and energy nutrient support
  • Detox pathways that may impair cellular energy
  • Secure digital access to over 1200 pages of content

All testing is processed in our ISO-certified Perth lab and delivered online through our encrypted portal.

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Available in Australia and New Zealand

Life X DNA™ kits are available for shipping and return across Australia and New Zealand. Your data is never shared or sold, and reports are structured for clarity and personal use.

FAQs – Genetics and Mitochondrial Function

Common symptoms include persistent fatigue, poor stamina, low mental energy and difficulty recovering after physical or emotional stress.

Yes. Variants in genes related to energy production and oxidative stress defence may contribute to slower or less efficient cellular energy output.

We analyse NQO1, UCP2, SOD2, MT-ND genes, PPARGC1A and others linked to energy, detox and cellular stress.

 Order a Life X DNA™ kit online, collect your cheek swab at home, and return it to our Perth lab. Your report will be securely available through our online portal.