Signs of Poor Methylation – What Do Your Genes Say?

We look at over 900,000 SNP’s and use the latest AI powered software to analyse over 80 million variants that significantly influence your health.

Methylation is a core biological process that affects energy, detox, neurotransmitter balance and immune response. If you’ve heard of MTHFR or suspect you have trouble with methylation, your genes may be worth exploring.

Life X DNA™ reports include detailed analysis of methylation-related genes, including MTHFR, MTR, MTRR, BHMT and more. Our test kits are available across Australia and New Zealand and provide insight into how well your methylation cycle may be working.

Genetic Methylation Tests Melbourne

What Are the Signs of Poor Methylation?

Symptoms of inefficient methylation may be broad and non-specific, but common patterns include:

  • Fatigue not relieved by rest
  • Mood swings or anxiety
  • Hormonal sensitivity or PMS
  • Trouble detoxing from alcohol or medications
  • B12 or folate sensitivity
  • Neurological or cognitive issues (e.g. brain fog, irritability)

These symptoms don’t prove poor methylation – but if persistent, genetics may offer insight into why.

Can Poor Methylation Be Genetic?

Yes. Methylation depends on enzymes that convert nutrients like folate, B12 and choline into active forms. These enzymes are coded by your DNA, and common gene variants can reduce their function.

Key methylation-related genes include:

  • MTHFR – converts folate into its active form (5-MTHF)
  • MTR – converts homocysteine into methionine using B12
  • MTRR – supports recycling of B12 for ongoing use
  • BHMT – part of the secondary methylation pathway
  • CBS – balances homocysteine and sulphur metabolism

When one or more of these genes are affected, methylation may slow down – increasing demands for nutrients or affecting stress and mood regulation.

MTHFR Tests Melbourne
DNA Health Tests Melbourne

Genetic Testing for Methylation Pathway Efficiency

Life X DNA™ testing provides insight into:

  • How your body processes and activates folate and B12
  • Whether your methylation cycle has slow or inefficient steps
  • Cofactor needs for B2, B6, B12, folate and choline
  • Interaction with mood, detox and hormone regulation genes

Reports are not diagnostic, but they offer evidence-informed explanations for persistent symptoms that haven’t improved through general strategies.

What’s Covered in Your Life X DNA™ Report

Your methylation profile includes:

  • MTHFR C677T and A1298C status
  • MTR, MTRR, BHMT, CBS and related genes
  • Summary of efficiency, nutrient support needs and gene interactions
  • Over 1200 pages of personalised, secure content

All kits are processed in our ISO-certified Perth lab, with results delivered through our encrypted portal.

MTHFR Tests Sydney

Available in Australia and New Zealand

We ship Life X DNA™ kits across Australia and New Zealand with prepaid return included. Your results are private, structured and accessible online.

FAQs – Methylation and Genetics

Symptoms may include low energy, mood shifts, B-vitamin sensitivity or difficulty recovering from stress. DNA insights can help clarify whether methylation may be involved.

No – but certain variants in MTHFR, MTR and other genes can make methylation more fragile or dependent on nutrient support.

We include MTHFR, MTR, MTRR, BHMT, CBS and others involved in folate and B12 metabolism.

Order online, complete your cheek swab, and return the sample to our Perth lab. Your report will be available securely through your Life X DNA™ portal.