Tired After Sleeping? – Could Your Fatigue Be Genetic?

We look at over 900,000 SNP’s and use the latest AI powered software to analyse over 80 million variants that significantly influence your health.

If you’re waking up exhausted even after a full night’s sleep, there may be more at play than just rest habits. For some people, chronic fatigue is influenced by their genes.

Life X DNA provides at-home genetic testing across Australia and New Zealand, including analysis of genes linked to energy production, sleep regulation and nutrient metabolism. Our reports help explore why your body may not be restoring energy effectively, even with good sleep hygiene.

Genetic Methylation Tests Melbourne

Can Fatigue Be Genetic?

Yes – your baseline energy, recovery ability and sleep architecture can all be affected by inherited genetic variation.

Some of the genes commonly associated with persistent tiredness include:

  • NQO1 – supports mitochondrial energy production and antioxidant activity
  • UCP2 – involved in energy regulation at the cellular level
  • PER3 – linked to circadian rhythm and sleep efficiency
  • MT-ND family – mitochondrial genes involved in ATP production
  • COMT and MAOA – influence mental fatigue and neurotransmitter balance

Variations in these genes may influence how well your body produces usable energy, clears oxidative stress, and restores itself during sleep.

Why Am I Still Tired After Sleeping Well?

Even with 7–9 hours of sleep, some people experience:

  • Poor mitochondrial function and inefficient energy generation
  • Disrupted sleep architecture due to circadian gene variation
  • Poor recovery from oxidative stress or inflammation
  • Nutrient processing issues that affect energy metabolism

A DNA test can’t confirm a medical diagnosis, but it can show whether your energy pathways may need extra support.

MTHFR Tests Melbourne
DNA Health Tests Melbourne

Genetic Testing for Chronic Fatigue Patterns

Life X DNA testing includes:

  • Mitochondrial function and antioxidant response genes
  • Sleep regulation and circadian rhythm-related genes
  • Nutrient pathways for energy cofactors (e.g. B vitamins, magnesium, carnitine)
  • Inflammation and stress recovery markers

These insights may help explain ongoing fatigue despite good lifestyle habits.

What Genes Affect Energy Despite Sleep?

Your report includes information on:

  • Cellular energy metabolism and mitochondrial efficiency
  • Neurotransmitter clearance and mental energy
  • Detox and oxidative stress capacity
  • Hormonal and circadian influences on recovery

All results are delivered through a secure digital platform and processed in our ISO-certified Perth lab.

Genetic Methylation Tests New Zealand

Available in Australia and New Zealand

Life X DNA test kits ship across Australia and New Zealand. All data is stored securely, not sold or shared, and used only to generate your report.

FAQs – Genetics and Persistent Fatigue

Genetics may influence how your body produces energy and recovers during rest. Factors like mitochondrial function, circadian rhythm, and stress genes can play a role.

No. Life X DNA is not a diagnostic tool, but it may highlight pathways that help explain why fatigue persists.

We analyse NQO1, UCP2, MT-ND family genes, PER3, COMT and others related to energy production and recovery.

Order online, complete your cheek swab at home, and return the kit to our Perth lab. Your report will be available securely online.